Jobs & studentships

Jobs and studentships in skeletal research can be posted here free of charge
Advertisements should contain a brief description, an e-mail address and/or web location for obtaining further details, and the closing date.
Simply send details to:   t.arnett@ucl.ac.uk
Other useful websites when looking for jobs are:

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POSITIONS OPEN

 

RVC fully funded (EU/UK) PhD: Gene therapy for cartilage regeneration in osteoarthritis

The Royal Veterinary College, University of London.    Closing date: Sun 9 Feb 2020.

https://www.rvc.ac.uk/study/postgraduate/phd/studentships/Gene_therapy_for_cartilage_regeneration_in_osteoarthritis

Osteoarthritis (OA) is the most common form of arthritis in humans. By 2050 it is estimated that 40 million people worldwide will be severely disabled by this disease. OA is characterized by the alteration of joint homeostasis and an anabolic/catabolic imbalance in the cells resident within joint tissues. Central to the disease is the loss of cartilage integrity resulting in large erosions. A key event in OA pathology is the transition of the stable articular cartilage chondrocyte into a catabolic hypertrophic chondrocyte. These hypertrophic cells secrete matrix-degrading enzymes, growth factors and pro-inflammatory mediators that destroy matrix and cause ‘normal’ chondrocytes to transition to hypertrophy. This project aims to develop a gene therapy solution to reverse this pathological process and induce articular cartilage regeneration.
Viral introduction of genes to the joint environment has recently been shown to be an effective strategy to control inflammatory processes in horse OA models, and is currently being developed for veterinary and human applications. Herein, we propose the viral delivery of a protein with regenerative potential in OA. It is envisaged that this project will contribute to the development of a therapeutic with applications to equine and human medicine. Indeed, data exists to suggest that disease modification will be achieved in both species. This is of importance as currently there is no approved drug that can modify disease in OA.
We are seeking a highly motivated student to advance this exciting gene therapy project.  As the successful candidate, you will have the opportunity to be at the cutting edge of regenerative medicine and OA therapeutic development.

Dr Scott Roberts: sjroberts@rvc.ac.uk

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BBSRC funded collaborative project between Southampton, Kent, Portsmouth, Oxford and DSTL  (Jan 2020)

website:  https://research.kent.ac.uk/socobio/nanodroplet-emulsions-for-oxygen-delivery-in-bone-repair/

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University of Portsmouth Molecular mechanisms of cognitive impairment caused by DMD gene mutations  (Jan 2020)

https://www.findaphd.com/phds/project/molecular-mechanisms-of-cognitive-impairment-caused-by-dmd-gene-mutations/?p116133

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University of Portsmouth Role of DMD gene in development and function of white blood cells  (Jan 2020)

https://www.findaphd.com/phds/project/role-of-dmd-gene-in-development-and-function-of-white-blood-cells/?p116137

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University of Portsmouth DMD gene in development and cancer   (Jan 2020)

https://www.findaphd.com/phds/project/dmd-gene-in-development-and-cancer/?p116135

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The role of P2X7 purinoceptor-bacteria interactions in the pathophysiology and treatment of Periodontitis  (Jan 2020)

https://www.findaphd.com/phds/project/the-role-of-p2x7-purinoceptor-bacteria-interactions-in-the-pathophysiology-and-treatment-of-periodontitis/?p116107

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University of Portsmouth  Role of Bacteria-Purinoceptor Interactions in Pathological Changes Leading to Implant Failure   (Jan 2020)

https://www.findaphd.com/phds/project/role-of-bacteria-purinoceptor-interactions-in-pathological-changes-leading-to-implant-failure/?p116273

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– page last updated by Tim Arnett on 14.01.20 –